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» Aligning alignments exactly
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BIBE
2010
IEEE
144views Bioinformatics» more  BIBE 2010»
15 years 8 months ago
Knowledge-Guided Docking of Flexible Ligands to SH2 Domain Proteins
Studies of interactions between protein domains and ligands are important in many aspects such as cellular signaling and regulation. In this work, we applied a three-stage knowledg...
Haiyun Lu, Shamima Banu Bte Sm Rashid, Hao Li, Wee...
ECAI
2010
Springer
15 years 7 months ago
Learning to Author Text with textual CBR
Abstract. Textual reuse is an integral part of textual case-based reasoning (TCBR) which deals with solving new problems by reusing previous similar problem-solving experiences doc...
Ibrahim Adeyanju, Nirmalie Wiratunga, Juan A. Reci...
BMCBI
2010
148views more  BMCBI 2010»
15 years 7 months ago
Calling SNPs without a reference sequence
Background: The most common application for the next-generation sequencing technologies is resequencing, where short reads from the genome of an individual are aligned to a refere...
Aakrosh Ratan, Yu Zhang, Vanessa M. Hayes, Stephan...
BMCBI
2010
123views more  BMCBI 2010»
15 years 7 months ago
A new protein binding pocket similarity measure based on comparison of clouds of atoms in 3D: application to ligand prediction
Background: Predicting which molecules can bind to a given binding site of a protein with known 3D structure is important to decipher the protein function, and useful in drug desi...
Brice Hoffmann, Mikhail Zaslavskiy, Jean-Philippe ...
BMCBI
2010
129views more  BMCBI 2010»
15 years 7 months ago
Detection of distant evolutionary relationships between protein families using theory of sequence profile-profile comparison
Background: Detection of common evolutionary origin (homology) is a primary means of inferring protein structure and function. At present, comparison of protein families represent...
Mindaugas Margelevicius, Ceslovas Venclovas