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BMCBI
2008
135views more  BMCBI 2008»
15 years 7 months ago
Ab-origin: an enhanced tool to identify the sourcing gene segments in germline for rearranged antibodies
Background: In the adaptive immune system, variable regions of immunoglobulin (IG) are encoded by random recombination of variable (V), diversity (D), and joining (J) gene segment...
Xiaojing Wang, Di Wu, SiYuan Zheng, Jing Sun, Lin ...
BMCBI
2008
140views more  BMCBI 2008»
15 years 7 months ago
GORouter: an RDF model for providing semantic query and inference services for Gene Ontology and its associations
Background: The most renowned biological ontology, Gene Ontology (GO) is widely used for annotations of genes and gene products of different organisms. However, there are shortcom...
Qingwei Xu, Yixiang Shi, Qiang Lu, Guo-qing Zhang,...
BMCBI
2011
15 years 2 months ago
The impact of quantitative optimization of hybridization conditions on gene expression analysis
Background: With the growing availability of entire genome sequences, an increasing number of scientists can exploit oligonucleotide microarrays for genome-scale expression studie...
Peter Sykacek, David P. Kreil, Lisa A. Meadows, Ri...
BMCBI
2007
94views more  BMCBI 2007»
15 years 7 months ago
False positive reduction in protein-protein interaction predictions using gene ontology annotations
Background: Many crucial cellular operations such as metabolism, signalling, and regulations are based on protein-protein interactions. However, the lack of robust protein-protein...
Mahmood A. Mahdavi, Yen-Han Lin
BMCBI
2007
102views more  BMCBI 2007»
15 years 7 months ago
Understanding and using the meaning of statements in a bio-ontology: recasting the Gene Ontology in OWL
The bio-ontology community falls into two camps: first we have biology domain experts, who actually hold the knowledge we wish to capture in ontologies; second, we have ontology s...
Mikel Egaña Aranguren, Sean Bechhofer, Phil...