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BMCBI
2010
101views more  BMCBI 2010»
15 years 7 months ago
Comparative analysis of thermophilic and mesophilic proteins using Protein Energy Networks
Background: Thermophilic proteins sustain themselves and function at higher temperatures. Despite their structural and functional similarities with their mesophilic homologues, th...
M. S. Vijayabaskar, Saraswathi Vishveshwara
BMCBI
2007
154views more  BMCBI 2007»
15 years 7 months ago
Bounds on the distribution of the number of gaps when circles and lines are covered by fragments: Theory and practical applicati
Background: The question of how a circle or line segment becomes covered when random arcs are marked off has arisen repeatedly in bioinformatics. The number of uncovered gaps is o...
John Moriarty, Julian R. Marchesi, Anthony Metcalf...
BMCBI
2007
62views more  BMCBI 2007»
15 years 7 months ago
Missing channels in two-colour microarray experiments: Combining single-channel and two-channel data
Background: There are mechanisms, notably ozone degradation, that can damage a single channel of two-channel microarray experiments. Resulting analyses therefore often choose betw...
Andy G. Lynch, David E. Neal, John D. Kelly, Glyn ...
BMCBI
2008
115views more  BMCBI 2008»
15 years 7 months ago
Systems biology driven software design for the research enterprise
Background: In systems biology, and many other areas of research, there is a need for the interoperability of tools and data sources that were not originally designed to be integr...
John Boyle, Christopher C. Cavnor, Sarah A. Killco...
BMCBI
2007
153views more  BMCBI 2007»
15 years 7 months ago
Estimating genealogies from linked marker data: a Bayesian approach
Background: Answers to several fundamental questions in statistical genetics would ideally require knowledge of the ancestral pedigree and of the gene flow therein. A few examples...
Dario Gasbarra, Matti Pirinen, Mikko J. Sillanp&au...