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RECOMB
2008
Springer
16 years 7 months ago
Algorithms for Joint Optimization of Stability and Diversity in Planning Combinatorial Libraries of Chimeric Proteins
Abstract. In engineering protein variants by constructing and screening combinatorial libraries of chimeric proteins, two complementary and competing goals are desired: the new pro...
Wei Zheng, Alan M. Friedman, Chris Bailey-Kellogg
RECOMB
2008
Springer
16 years 7 months ago
Accurate Computation of Likelihoods in the Coalescent with Recombination Via Parsimony
Understanding the variation of recombination rates across a given genome is crucial for disease gene mapping and for detecting signatures of selection, to name just a couple of app...
Jotun Hein, Rune B. Lyngsø, Yun S. Song
RECOMB
2005
Springer
16 years 7 months ago
Information Theoretic Approaches to Whole Genome Phylogenies
We describe a novel method for efficient reconstruction of phylogenetic trees, based on sequences of whole genomes or proteomes, whose lengths may greatly vary. The core of our me...
David Burstein, Igor Ulitsky, Tamir Tuller, Benny ...
RECOMB
2003
Springer
16 years 7 months ago
Physical network models and multi-source data integration
We develop a new framework for inferring models of transcriptional regulation. The models in this approach, which we call physical models, are constructed on the basis of verifiab...
Chen-Hsiang Yeang, Tommi Jaakkola
STOC
2001
ACM
122views Algorithms» more  STOC 2001»
16 years 7 months ago
Provisioning a virtual private network: a network design problem for multicommodity flow
Consider a setting in which a group of nodes, situated in a large underlying network, wishes to reserve bandwidth on which to support communication. Virtual private networks (VPNs...
Anupam Gupta, Jon M. Kleinberg, Amit Kumar, Rajeev...