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BMCBI
2008
106views more  BMCBI 2008»
15 years 7 months ago
SpliceCenter: A suite of web-based bioinformatic applications for evaluating the impact of alternative splicing on RT-PCR, RNAi,
Background: Over 60% of protein-coding genes in vertebrates express mRNAs that undergo alternative splicing. The resulting collection of transcript isoforms poses significant chal...
Michael C. Ryan, Barry Zeeberg, Natasha J. Caplen,...
BMCBI
2010
154views more  BMCBI 2010»
15 years 7 months ago
Candidate gene prioritization by network analysis of differential expression using machine learning approaches
Background: Discovering novel disease genes is still challenging for diseases for which no prior knowledge - such as known disease genes or disease-related pathways - is available...
Daniela Nitsch, Joana P. Gonçalves, Fabian ...
BMCBI
2007
99views more  BMCBI 2007»
15 years 7 months ago
Statistical significance of cis-regulatory modules
Background: It is becoming increasingly important for researchers to be able to scan through large genomic regions for transcription factor binding sites or clusters of binding si...
Dustin E. Schones, Andrew D. Smith, Michael Q. Zha...
BMCBI
2008
135views more  BMCBI 2008»
15 years 7 months ago
Identification of a small optimal subset of CpG sites as bio-markers from high-throughput DNA methylation profiles
Background: DNA methylation patterns have been shown to significantly correlate with different tissue types and disease states. High-throughput methylation arrays enable large-sca...
Hailong Meng, Edward Lenn Murrelle, Guoya Li
BMCBI
2007
126views more  BMCBI 2007»
15 years 7 months ago
Reconstruction of cell population dynamics using CFSE
Background: Quantifying cell division and death is central to many studies in the biological sciences. The fluorescent dye CFSE allows the tracking of cell division in vitro and i...
Andrew Yates, Cliburn Chan, Jessica Strid, Simon M...
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