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220
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BMCBI
2010
15 years 7 months ago
2010
Background: Matrix metalloproteinases (MMPs) are well-known biological targets implicated in tumour progression, homeostatic regulation, innate immunity, impaired delivery of pro-...
241
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BMCBI
2010
15 years 7 months ago
2010
Background: There is an increasing demand to assemble and align large-scale biological sequence data sets. The commonly used multiple sequence alignment programs are still limited...
197
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BMCBI
2007
15 years 7 months ago
2007
Background: By virtue of their shared ancestry, homologous sequences are similar in their structure and function. Consequently, multiple sequence alignments are routinely used to ...
172
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BMCBI
2007
15 years 7 months ago
2007
Background: G Protein-Coupled Receptors (GPCRs) are a large and diverse family of membrane proteins whose members participate in the regulation of most cellular and physiological ...
199
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BMCBI
2008
15 years 7 months ago
2008
Background: Identifying the active site of an enzyme is a crucial step in functional studies. While protein sequences and structures can be experimentally characterized, determini...