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BMCBI
2010
100views more  BMCBI 2010»
15 years 7 months ago
Trimming of mammalian transcriptional networks using network component analysis
Background: Network Component Analysis (NCA) has been used to deduce the activities of transcription factors (TFs) from gene expression data and the TF-gene binding relationship. ...
Linh M. Tran, Daniel R. Hyduke, James C. Liao
BMCBI
2010
118views more  BMCBI 2010»
15 years 7 months ago
Bacillus anthracis genome organization in light of whole transcriptome sequencing
Emerging knowledge of whole prokaryotic transcriptomes could validate a number of theoretical concepts introduced in the early days of genomics. What are the rules connecting gene...
Jeffrey Martin, Wenhan Zhu, Karla D. Passalacqua, ...
BMCBI
2010
105views more  BMCBI 2010»
15 years 7 months ago
Comparison of PGH2 binding site in prostaglandin synthases
Background: Prostaglandin H2 (PGH2) is a common precursor for the synthesis of five different Prostanoids via specific Prostanoid Synthases. The binding of this substrate with the...
Padmapriya Paragi-Vedanthi, Mukesh Doble
BMCBI
2010
103views more  BMCBI 2010»
15 years 7 months ago
Virtual Screening of potential drug-like inhibitors against Lysine/DAP pathway of Mycobacterium tuberculosis
Background: An explosive global spreading of multidrug resistant Mycobacterium tuberculosis (Mtb) is a catastrophe, which demands an urgent need to design or develop novel/potent ...
Aarti Garg, Rupinder Tewari, Gajendra P. S. Raghav...
BMCBI
2010
84views more  BMCBI 2010»
15 years 7 months ago
An integrated analysis of molecular aberrations in NCI-60 cell lines
Background: Cancer is a complex disease where various types of molecular aberrations drive the development and progression of malignancies. Large-scale screenings of multiple type...
Chen-Hsiang Yeang
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