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BMCBI
2010
84views more  BMCBI 2010»
15 years 7 months ago
A variational Bayes algorithm for fast and accurate multiple locus genome-wide association analysis
Background: The success achieved by genome-wide association (GWA) studies in the identification of candidate loci for complex diseases has been accompanied by an inability to expl...
Benjamin A. Logsdon, Gabriel E. Hoffman, Jason G. ...
DLS
2010
204views Languages» more  DLS 2010»
15 years 5 months ago
Alias analysis for optimization of dynamic languages
Dynamic languages such as Python allow programs to be written more easily using high-level constructs such as comprehensions for queries and using generic code. Efficient executio...
Michael Gorbovitski, Yanhong A. Liu, Scott D. Stol...
BMCBI
2010
151views more  BMCBI 2010»
15 years 7 months ago
CCRaVAT and QuTie - enabling analysis of rare variants in large-scale case control and quantitative trait association studies
Background: Genome-wide association studies have been successful in finding common variants influencing common traits. However, these associations only account for a fraction of t...
Robert Lawrence, Aaron G. Day-Williams, Katherine ...
BMCBI
2010
112views more  BMCBI 2010»
15 years 7 months ago
PhenoFam-gene set enrichment analysis through protein structural information
Background: With the current technological advances in high-throughput biology, the necessity to develop tools that help to analyse the massive amount of data being generated is e...
Maciej Paszkowski-Rogacz, Mikolaj Slabicki, M. Ter...
BMCBI
2008
117views more  BMCBI 2008»
15 years 7 months ago
New resampling method for evaluating stability of clusters
Background: Hierarchical clustering is a widely applied tool in the analysis of microarray gene expression data. The assessment of cluster stability is a major challenge in cluste...
Irina Gana Dresen, Tanja Boes, Johannes Hüsin...