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165
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BMCBI
2008
15 years 7 months ago
2008
Background: Designing small-molecule kinase inhibitors with desirable selectivity profiles is a major challenge in drug discovery. A high-throughput screen for inhibitors of a giv...
180
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BMCBI
2010
15 years 7 months ago
2010
Background: We study the usage of specific peptide platforms in protein composition. Using the pentapeptide as a unit of length, we find that in the universal proteome many pentap...
176
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BMCBI
2008
15 years 7 months ago
2008
Background: Modern sequencing technologies allow rapid sequencing and bioinformatic analysis of genomes and metagenomes. With every new sequencing project a vast number of new pro...
178
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BMCBI
2008
15 years 7 months ago
2008
Background: The identification and characterization of interacting domain pairs is an important step towards understanding protein interactions. In the last few years, several met...
188
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BMCBI
2008
15 years 7 months ago
2008
Background: Structural alignment is an important step in protein comparison. Well-established methods exist for solving this problem under the assumption that the structures under...