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BMCBI
2010
99views more  BMCBI 2010»
15 years 7 months ago
Different effects of the probe summarization algorithms PLIER and RMA on high-level analysis of Affymetrix exon arrays
Background: Alternative splicing is an important mechanism that increases protein diversity and functionality in higher eukaryotes. Affymetrix exon arrays are a commercialized pla...
Yi Qu, Fei He, Yuchen Chen
BMCBI
2010
118views more  BMCBI 2010»
15 years 7 months ago
Walk-weighted subsequence kernels for protein-protein interaction extraction
Background: The construction of interaction networks between proteins is central to understanding the underlying biological processes. However, since many useful relations are exc...
Seonho Kim, Juntae Yoon, Jihoon Yang, Seog Park
BMCBI
2010
104views more  BMCBI 2010»
15 years 7 months ago
A novel scoring function for discriminating hyperthermophilic and mesophilic proteins with application to predicting relative th
Background: The ability to design thermostable proteins is theoretically important and practically useful. Robust and accurate algorithms, however, remain elusive. One critical pr...
Yunqi Li, C. Russell Middaugh, Jianwen Fang
BMCBI
2008
111views more  BMCBI 2008»
15 years 7 months ago
Comparative optimism in models involving both classical clinical and gene expression information
Background: In cancer research, most clinical variables have already been investigated and are now well established. The use of transcriptomic variables has raised two problems: r...
Caroline Truntzer, Delphine Maucort-Boulch, Pascal...
BMCBI
2008
126views more  BMCBI 2008»
15 years 7 months ago
Combining Shapley value and statistics to the analysis of gene expression data in children exposed to air pollution
Background: In gene expression analysis, statistical tests for differential gene expression provide lists of candidate genes having, individually, a sufficiently low p-value. Howe...
Stefano Moretti, Danitsja van Leeuwen, Hans Gmuend...
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