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NIPS
2003
15 years 9 months ago
Minimax Embeddings
Spectral methods for nonlinear dimensionality reduction (NLDR) impose a neighborhood graph on point data and compute eigenfunctions of a quadratic form generated from the graph. W...
Matthew Brand
NIPS
1997
15 years 9 months ago
EM Algorithms for PCA and SPCA
I present an expectation-maximization (EM) algorithm for principal component analysis (PCA). The algorithm allows a few eigenvectors and eigenvalues to be extracted from large col...
Sam T. Roweis
BMCBI
2010
104views more  BMCBI 2010»
15 years 7 months ago
A novel chemogenomics analysis of G protein-coupled receptors (GPCRs) and their ligands: a potential strategy for receptor de-or
Background: G protein-coupled receptors (GPCRs) represent a family of well-characterized drug targets with significant therapeutic value. Phylogenetic classifications may help to ...
Eelke van der Horst, Julio E. Peironcely, Adriaan ...
BMCBI
2006
141views more  BMCBI 2006»
15 years 7 months ago
Identification of consensus RNA secondary structures using suffix arrays
Background: The identification of a consensus RNA motif often consists in finding a conserved secondary structure with minimum free energy in an ensemble of aligned sequences. How...
Mohammad Anwar, Truong Nguyen, Marcel Turcotte
BMCBI
2006
125views more  BMCBI 2006»
15 years 7 months ago
Automated functional classification of experimental and predicted protein structures
Background: Proteins that are similar in sequence or structure may perform different functions in nature. In such cases, function cannot be inferred from sequence or structural si...
Kai Wang, Ram Samudrala