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BMCBI
2008
124views more  BMCBI 2008»
15 years 7 months ago
A relation based measure of semantic similarity for Gene Ontology annotations
Background: Various measures of semantic similarity of terms in bio-ontologies such as the Gene Ontology (GO) have been used to compare gene products. Such measures of similarity ...
Brendan Sheehan, Aaron J. Quigley, Benoit Gaudin, ...
BMCBI
2007
227views more  BMCBI 2007»
15 years 7 months ago
Growing functional modules from a seed protein via integration of protein interaction and gene expression data
Background: Nowadays modern biology aims at unravelling the strands of complex biological structures such as the protein-protein interaction (PPI) networks. A key concept in the o...
Ioannis A. Maraziotis, Konstantina Dimitrakopoulou...
BMCBI
2007
179views more  BMCBI 2007»
15 years 7 months ago
Automated smoother for the numerical decoupling of dynamics models
Background: Structure identification of dynamic models for complex biological systems is the cornerstone of their reverse engineering. Biochemical Systems Theory (BST) offers a pa...
Marco Vilela, Carlos Cristiano H. Borges, Susana V...
BMCBI
2008
96views more  BMCBI 2008»
15 years 7 months ago
Novel methodology for construction and pruning of quasi-median networks
Background: Visualising the evolutionary history of a set of sequences is a challenge for molecular phylogenetics. One approach is to use undirected graphs, such as median network...
Sarah C. Ayling, Terence A. Brown
BMCBI
2007
160views more  BMCBI 2007»
15 years 7 months ago
Optimization based automated curation of metabolic reconstructions
Background: Currently, there exists tens of different microbial and eukaryotic metabolic reconstructions (e.g., Escherichia coli, Saccharomyces cerevisiae, Bacillus subtilis) with...
Vinay Satish Kumar, Madhukar S. Dasika, Costas D. ...