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BMCBI
2008
176views more  BMCBI 2008»
15 years 7 months ago
H2r: Identification of evolutionary important residues by means of an entropy based analysis of multiple sequence alignments
Background: A multiple sequence alignment (MSA) generated for a protein can be used to characterise residues by means of a statistical analysis of single columns. In addition to t...
Rainer Merkl, Matthias Zwick
BMCBI
2008
123views more  BMCBI 2008»
15 years 7 months ago
A tree-based conservation scoring method for short linear motifs in multiple alignments of protein sequences
Background: The structure of many eukaryotic cell regulatory proteins is highly modular. They are assembled from globular domains, segments of natively disordered polypeptides and...
Claudia Chica, Alberto Labarga, Cathryn M. Gould, ...
BMCBI
2006
143views more  BMCBI 2006»
15 years 7 months ago
Fast estimation of the difference between two PAM/JTT evolutionary distances in triplets of homologous sequences
Background: The estimation of the difference between two evolutionary distances within a triplet of homologs is a common operation that is used for example to determine which of t...
Christophe Dessimoz, Manuel Gil, Adrian Schneider,...
BMCBI
2004
125views more  BMCBI 2004»
15 years 7 months ago
A functional hierarchical organization of the protein sequence space
Background: It is a major challenge of computational biology to provide a comprehensive functional classification of all known proteins. Most existing methods seek recurrent patte...
Noam Kaplan, Moriah Friedlich, Menachem Fromer, Mi...
LCTRTS
2010
Springer
15 years 5 months ago
Improving both the performance benefits and speed of optimization phase sequence searches
The issues of compiler optimization phase ordering and selection present important challenges to compiler developers in several domains, and in particular to the speed, code size,...
Prasad A. Kulkarni, Michael R. Jantz, David B. Wha...